 Keratoconus research is moving forward on many fronts. Laboratory scientists are searching for the elusive cause (or causes) of keratoconus by examining the ways in which the KC cornea differs from the normal cornea and clinical scientists are looking for better treatment options to improve the quality of life for those with KC.
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*October 2010
What makes KC corneas different than normal corneas? In this 30 minute program Dr. M. Cristina Kenney discusses the three major pathological features that characterize keratoconus: corneal thinning, oxidative damage and anterior corneal instability. She will also discuss mitochondria (mtDNA) and the role they play in keratoconus.
Click on the arrow to start the presentation.
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*September 2009
Keraflex KXL is the newest procedure under investigation for the treatment of keratoconus. It is non-incisional and reshapes the cornea without removing any tissue preserving the biomechanical integrity of the cornea. It is currently under clinical investigation in Europe for treating myopia and keratoconus, and the company, Avedro, plans to file for an FDA IDE in the United States in mid-2010.
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*November 2009
Optical-imaging technologies show hope for preventing KC and other diseases
Optical imaging devices using novel laser-scanning technologies are allowing scientists to study cell processes in the eye with more depth and meaning than ever before. Using High-Resolution Laser Macroscopy, scientists at UC Irvine have been able to map out the unique, rigid structure of the human cornea. The “macroscope” creates three-dimensional data sets that, when put together, produce an accurate, full representation of the human cornea.
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*September 2009
In a longitudinal study, researchers at the Cornea-Genetic Eye Institute, Cedars-Sinai Medical Center in Los Angeles, California studied clinical signs and topography (videokeratography) maps of eyes in four groups of patients to determine whether there would be a useful correlation between the maps and clinical signs of keratoconus that might be used to detect subclinical keratoconus.
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*July 2009
WGSLs are Wavefront-Guided Soft contact Lenses. This novel contact lens technology has recently received funding by the NIH and is under development at The Visual Optics Institute (VOI) at The University of Houston, College of Optometry (UHCO). These lenses created using using wavefront sensing will correct highly aberrated optics of the eye as seen specifically in keratoconus.
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*November 2009
While it is recognized that keratoconus involves a generalized mechanical weakening of the central cornea leading to corneal steepening and cone formation, the mechanism underlying this change has yet to be identified. We have recently received National Institute of Health support from the National Eye Institute to begin to unravel this unknown mechanism.
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*March 2009
A team at Cardiff University in the UK is using synchrotron radiation to advance the understanding and treatment of eye diseases like keratoconus.
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*September 2008
The U.S. Food and Drug Administration (FDA) recently permitted the start of three clinical trials in the United States to evaluate the safety and effectiveness of riboflavin/UVA light corneal collagen cross-linking (CXL) in patients with progressive keratoconus or corneal ectasia after previous refractive surgery.
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