Research Overview



History Of Keratoconus Research
There have been milestone discoveries that have furthered the research efforts in KC. We know that keratoconus is a noninflammatory, thinning condition of the cornea. In 1963, scientists found that the initial changes of KC were related to degradation (break down) of the cornea¹s basement membrane.
read more…
Current Keratoconus Research
Even with all the historical research, it was difficult to understand how the ALDH story and the increased activity of degradative enzymes were related to each other. Work in our laboratory (Cedars-Sinai Medical Center, Los Angeles) examined another pathway by which the cornea can process the free radicals: a series of interactions with nitric oxide.
read more…
Future Keratoconus Research
Our working hypothesis is that in keratoconus there are various factors (such as UVB, atopy/allergy, and mechanical eye rubbing) that can cause either oxidative damage or disruption of the cellular structure or function.
read more…